The mysterious obelisk known only as "the Talisman" is an object of great mystery and mind aggravating confusion. It possess the ability to alter the physiology of seemingly any creature as well as having ties to Cybertron, its colony world of Eukaris and Microspace. Befitting any artifact of cosmic power, it's also sought after by a myriad of international criminals.
When Onyx sent the Axalon to find the Enigma of Combination, he entrusted the Talisman to the crew. The ship arrived on Earth to restock on Energon where Shockwave shot it down in an attempt to protect his experiment. The Talisman scrambled the crew's memories on impact and after reprogramming them to conduct an experiment, Shockwave proceeded to study the Talisman noting with interest its spontaneous creation of a drone force from the Axalon's hull. After a brief period of this, he went off to conduct his experiments and fell into stasis lock, the Talisman becoming buried in ice and snow.
As the false memories of the Eukarians wore off, they attempted to find the relic with one of them tracking down the pyramid where it would be but none of them found it.
The IRON Troopers had in fact brought the Talisman back to the Axalon. During World War II, Sgt. Savage and Garrison Kreiger encountered Centurion, last of the Axalon crew who told them about the Talisman, still buried in the wreck of the Axalon. The three travelled to the ship only to find the Talisman had commanded the IRON Troopers to puppeteer the corpse of Domitius Major. Flying into a rage at the desecration of his friend's body, Centurion attacked with a fury and dismembered Domitius destroying the IRON Troopers in the process. The Talisman viewed this an attack and teleported itself, the Axalon and Savage away. Kreiger was mesmerized by the Talisman's power and manipulated Centurion into aiding him.
One way or another, the Talisman wound up buried in an Egyptian tomb. Somehow during the intervening years it had come into with contact Dire Wraith, gaining Wraith tendrils surrounding its front emblem. When Kreiger found it in the 1980s, he was followed by the Adventure Team and Soundwave tracking the signal for the mysterious drones. The priceless pyramid surrounding the Talisman proved little obstacle to Soundwave who rammed through layer after layer of stone until he found Kreiger who sent the IRON Troopers on the Decepticon. Soundwave defeated them with ease but one of Atomic Man's arms was damaged in the crossfire who touched the Talisman and received an upgraded model with the ability to project forcefields. While intrigued by the relic's power, Soundwave decided it was more trouble than it was worth due to the Troopers and organics and simply flew off to complete his mission. The Talisman then fell into Kreiger's possession, who managed to construct a replica.
The Talisman was placed in Schleteva as bait where it was tracked down by Garrison Blackrock who believed it could restore his memories. He somehow accessed the Wraith DNA within which turned the people above into Wraith mutates. After some initial confusion on the heroes' part, the Talisman was teleported away by the Oktober Guard, to a Cobra moon base where Baron Ironblood and Mercy Gale tried to jumpstart it using Ore-13. Action Man had been caught in the teleport and when he was rescued, the villains were forced to leave the relic behind where upon it was piloted back to Earth by Larissa who marvelled at its construction and noted the many slots for enerchanging.